Abstract
The study of host-pathogen interactions in model organisms offers a means to characterize mechanisms and new critical innate immune genes that are conserved in higher eukaryotes. In vertebrates, leukotriene A4 hydrolase (LTA4H) is known to play a role in bacterial growth restriction. Planarian, a non-vertebrate organism, has the extraordinary ability to fight a wide spectrum of bacterial pathogens and have the faculty to regenerate an entire organism from a tissue fragment. However, the antibacterial response of the planarian remains poorly understood. We evaluated the contribution of LTA4H in the antibacterial response of the planarian, and we have observed that the silencing of the Smed-LTA4H gene by RNA interference promotes the S. aureus clearance, suggesting a role of LTA4H in the microbicidal activity of planarians.
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