Abstract
Purpose: During aging the extracellular matrix (ECM) of cartilage gets stiffer due to the action of ECM cross linking enzymes. The lysyl oxidase (LOX) is an important player in this process as it contributes to the crosslinking of collagen fibers. Matrix stiffness is known to regulate Yap/ TAZ signaling, which interferes with canonical WNT signaling and thereby regulates cell differentiation. Increased cytosolic Yap levels increase the degradation of ß-catenin thereby downregulating canonical Wnt signaling.
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