Abstract
Abstract When studied in an in vitro system with the use of a soluble thyroid iodide peroxidase-tyrosine iodinase, alpha methyl tyrosine (AMPT) competes with tyrosine for iodination and is itself iodinated. Alpha methyldopa (AMD) is a very potent inhibitor of iodination of soluble tyrosine and is not iodinated. AMD causes pronounced inhibition of soluble iodotyrosine formation at 5 μM and is almost completely inhibitory at 0.1 mM. Lineweaver-Burk plots suggest noncompetitive inhibition by AMD. In the usual therapeutic dose given to man for treatment of hypertension, AMD does not depress I 131 uptake.
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