Abstract
Because intestinal α-glucosidase plays a key role in carbohydrate digestion, its inhibition provides a therapeutic option for diabetes by suppressing postprandial blood glucose. We recently identified a grape seed extract (GSE) significantly inhibiting α-glucosidases. The inhibitory activity of GSE on yeast α-glucosidase was significantly stronger than that of acarbose. GSE also inhibited rat α-glucosidases in vitro in a dose- and time-dependent manner. The potential anti-diabetic effect of GSE was further evaluated in an animal model. Male 6 week-old C57BLK/6NCr mice were treated by streptozocin to induce diabetes. The results showed the oral intake of GSE (400mg/kg, body weight) suppressed postprandial blood glucose in STZ-induced diabetic mice. Oral administration of GSE reduced postprandial blood glucose in the diabetic mice by 11.5% and 16.6% at 30 and 60 min after the starch meal. Overall, GSE intake significantly reduced the incremental AUC0-120min (area under postprandial glycemic curve) by 27.3% as compared to the control. Our results strongly suggest the potential of developing GSE, as a novel inhibitor of α-glucosidases, for diabetes prevention and treatment.
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