Abstract
Diphenylhydantoin pretreatment of rats for 20 days resulted in a reversible inhibition (48%) of duodenal calcium accumulation in vitro without affecting calcium binding protein activity in the supernatant of duodenal homogenates. Active transport of hexoses and amino acids was not altered after diphenylhydantoin pretreatment. Increases in hexose-induced transmural potential differences did not differ between controls and diphenylhydantoin pretreated rats. Inhibition of intestinal calcium transport may be responsible for the biochemical abnormalities underlying osteomalacia in patients on anticonvulsant therapy.
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