Abstract
The intracerebroventricular administration of interleukin-1β (12.5 ng/kg) in rabbits caused a prompt rise of prostaglandin E 2 concentration (+632.6 ± 243.9%) in the cerebrospinal fluid followed by hyperthermia (+1.61 ± 0.14 Δ°C). The intracerebroventricular administration of an anti-inflammatory nonapeptide (amino acids 204–212, SHLRKVFDK) derived from lipocortin 5, thereafter referred to as lipocortin 5-(204–212)-peptide, inhibited in a significant manner both the increase in cerebrospinal fluid [prostaglandin E 2] and the febrile response induced by the cytokine. This inhibitory effect is probably due to interference by the peptide with phospholipase A 2 activity. A control peptide (FKRVHDLKS) formed by the same amino acids in a randomly shuffled sequence had no effect. These results show that, in addition to the anti-inflammatory effect previously reported, the peptide 204–212 of lipocortin 5 possesses, like glucocorticoids, anti-pyretic activity. The research on lipocortin-derived peptides may lead to the development of novel anti-inflammatory and anti-pyretic compounds.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
