Abstract
We designed experiments to determine if a nonsteroidal substance capable of inhibiting the secretion of follicle-stimulating hormone (FSH) exists in the hamster ovary. Proestrous hamster ovaries were homogenized, centrifuged, and treated with dextrancoated charcoal for removal of steroids. Charcoal-treated ovarian extract (CTOE) was injected intraperitoneally at hourly intervals into phenobarbital-treated (phen-treated) proestrous hamsters immediately after ovariectomy at 1300. The CTOE inhibited the selective rise in serum FSH that occurred in phen-treated, ovariectomized (ovx) controls.KeywordsLuteinizing HormoneFollicular FluidPituitary CellLuteinizing Hormone LevelAnterior Pituitary CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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