Abstract
OF the esters of di(4-hydroxycoumarinyl-3)-acetic acid (‘pelentanic acid’ according to Fucik, Prochazka and Cechova1), one, the ethyl ester (‘Pelentan’), has been widely used as an anticoagulant. It has been reported2 that ‘Pelentan’ is less toxic than dicoumarol, acts with less delay and is more quickly eliminated. During a pharmacological study of ‘Pelentan’, it was found that its solutions inhibit human serum cholinesterase. In continuation of these observations, a comparison has been made of the inhibition of serum cholinesterase by some esters of pelentanic acid and by dicoumarol.
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