Abstract
We have recently described the inhibition of human neutrophil elastase (HNE) by RNA purified from Streptococcus pneumoniae (1). Inhibition of this enzyme by a wide variety of polyanions has also been reported by others. Such agents include ribonucleic acids from yeast (1,2), E. coli (2), polyribosylribitol phosphate from H. influenzae capsules (1), and several sulfated polysaccharides (3-5). In addition to these naturally-occuring polyanions, synthetic RNA homopolymers were also tested previously (2).
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