Abstract
Halobacterium cutirubrum, an extremely halophilic bacterium, lacks a normal peptidoglycan cell wall. Nevertheless, bacitracin, a known inhibitor of peptidoglycan synthesis, has been shown to completely suppress the growth of this organism (Mescher & Strominger, 1975) In an attempt to clarify this observation, the effect of bacitracin on DNA, RNA, protein and lipid biosynthesis in H. cutirubrum was monitored. Lipid carbohydrate and lipid phosphate were the most affected. These observations were confirmed by uptake studies of [14glycerol into the membrane lipids. The possibility that bacitracin acts against H. cutirubrum through inhibition of dephosphorylation of the isoprenoid pyrophosphate precursors of this organism's diether lipids is discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
