Abstract
Objective To study the effects of angiostatin on the growth and metastasis of gastric cancer in vivo. Methods Metastatic model simulating human gastric cancer was established by orthotopic implantation of histologically intact human tumor tissue into gastric wall of nude mice. Results The MVD were decreased significantly in the treated mice ( P 0.05). The AI were increased significantly in the treated mice ( P 0.05). Tumor metastasis to the liver and peritoneaum was also significantly inhibited in a dose-dependent manner ( P 0.05). Conclusion Angiostatin can induce apoptosis in gastric cancer by inhibiting tumor angiogenesis and has strong inhibitory effect both on tumor growth and metastasis of human gastric cancer implanted in nude nude.
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