Abstract
SummaryGlucagon and cyclic adenosine-3′,5′-monophosphate (cAMP) markedly decreased glucose-U-14C oxidation and conversion into fatty acids in liver slices from fed and fasted–refed rats. Epinephrine was much less effective. Lipogenesis from fasted rats was not reduced by any of these compounds below the level already produced by 2-day fast. The data suggest that hepatic glucagon levels are important in regulating glucose oxidation and its conversion into fatty acids. This effect appears to be mediated via modification of hepatic tissue cAMP levels.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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