Abstract
An investigation was made on the effect of methylenecyclopropane-pyruvic acid on gluconeogenesis in vitro, using slices of rat kidney cortex. The compound is a metabolite of hypoglycin, which is the toxic amino acid occurring in the ackee plant ( Blighia sapida, König). Glucose production from a variety of precursors was found to be markedly inhibited, the agent being active at low concentrations (0.1 mM). The site of the block was located specifically at the fructose 1,6-diphosphatase reaction. However, the mechanism by which this effect is achieved is not known.
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