Abstract

1-(2-Pyrimidinyl)-4-imino-1,4-dihydropyridinium chloride, a hypoglycemie agent inhibits gluconeogenesis from lactate in the perfused guinea pig liver. The alterations in the concentrations of hepatic metabolites resemble those observed in the presence of phenylethylbiguanide and 1-methyl-4(3-methyl-5-isoxazolyl)-pyridinium chloride; reducing equivalents are increased while the ATP/ADP ratio and the hepatic cell respiration are decreased.

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