Abstract
1. Insect skeletal muscle is relatively insensitive to applied GABA, responses are elicited only when relatively high concentrations of GABA are used (>10 −6M). 2. Pretreatment of the muscle with the GABA uptake inhibitors nipecotic acid, β-aminobutyric acid or β-alanine increases the sensitivity of the muscle to GABA by as much as 1000-fold. 3. The evidence suggests the existence of a GABA uptake mechanism in the insect neuromuscular system which could reside in glial cells.
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