Abstract
C57BL mouse spleen cells incubated with (C57BL x 101) F/sub 1/ liver homogenate killed only 17% of sublethally irradiated (C57BL x 1O1)F/sub 1/ recipients, whereas when incubated with C57BL liver homogenate or injected without incubation such cells killed 100% of sublethally irradiated (C57BL x 1O1)F/sub 1/ recipients within 35 days. Although the immunologically inactivated spleen cells showed a decreased ability to kill, circulating donor-type erythrocytes were found in surviving recipients, indicating repopulation of the bone marrow by surviving graft-derived stem cells. From this, it is inferred that immunologic inactivation did not result from nonspecific destruction of all types of implanted cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
