Abstract
Sulfonylureas potentiate the cellular action of insulin, not by changing membrane receptor number as previously thought, but by unknown postbinding mechanisms. We investigated the direct effects of tolazamide on fatty acid oxidation in isolated intact liver mitochondria, prepared from fed and fasted rats. Total ketone body formation and CO2 production (x10% of total oxidative products) were measured using 1−14C palmitate. Ketogenesis results are expressed in nmols/min/mg prot. (± SEM).
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