Abstract
In experiments in rats, the in vivo effect of 4-iodo-pyrazole on ethanol metabolism was studied. An ethanol dose of 32·6 m-mole/kg was administered. Blood samples were withdrawn at regular intervals, and ethanol analyzed by the Widmark method and by gas chromatography. 4-iodo-pyrazole in doses of 0·05 to 1·25 m-mole/kg inhibited the metabolism of ethanol from 19 to 84 per cent, and the presence of ethanol in blood was prolonged from 4 hr in the controls to 28 hr in the experiment with 1·25 m-mole/kg 4-iodo-pyrazole. 4-iodo-pyrazole is a potent ADH blocker, the ed 50 being 0·27 m-mole/kg of the same order of magnitude as for pyrazole in vivo.
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