Abstract
IT HAS recently been reported (Weichert and Kerrigan, 1942) that injection of estrogen into lactating female rats has a profound effect upon the reproductive systems of the suckling young. Daily injections of .1 mg. of diethylstilbestrol begun on the day of parturition bring about, among other things, a striking cornification of the epithelium of the prostatic utricle, prostatic urethra and ejaculatory ducts. The lining of the bulbus urethra and duct of Cowper's gland becomes a highly stratified squamous epithelium. These reactions are very evident by the 14th day of life. Freud (1933), Lacassagne and Villela (1933), Burrows and Kenneway (1934), Burrows (1935a, b), deJongh (1935), Korenchevsky and Dennison (1935), Overholser and Nelson (1935), Weller, Overholser and Nelson (1936), Wells (1936), Burrows (1937), Rusch (1937) and Harsh, Overholser and Wells (1939) have injected estrogens directly into older normal and castrated male rats, mice and ground-squirrels and have observed metaplastic changes in the...
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