Abstract
We recently found that central administration of the cholinesterase inhibitor paraoxon lowered blood pressure substantially. It was postulated that the decrease in pressure was mediated by a reduction of sympathetic outflo. In the present study, efferent splanchnic nerve activity in anaesthesized and paralysed cats was recorded, and quantified by measuring the variance of signal amplitude. After administration of 8μg paraoxon into the vertebral arteries, blood pressure and splanchnic nerve activity decreased simulataneously. A mean fall of 46 ± 6% and 45 ± 13% ( X ± S.E.M.) respectively was reached within 12 min and was maintained during the perio studied (30 min). When the effect of paraoxon was antagonized by dexetimide, both blood pressure and splanchnic nerve activity returned to control values. Since previous work has shown that the depressor action could not be prevented by efferent vagal blockade it seems likely that the fall in blood pressure after paraoxon was mainly caused by a decreased symphathetic outflow. In addition, we varied the amplifier band width in recording splanchnic nerve activity. The measurement of frequencies between 10 and 225 Hz appeared to be sufficient for studying the change in activity after paraoxon.
Published Version
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