Inhibition of drinking by naltrexone in the rat: Interaction with the dopamine D-1 antagonist SCH 23390 and the D-2 antagonist sulpiride

Abstract

The involvement of dopamine receptors in water intake was investigated in the rat deprived of water for 24 hr. A 0.03 mg/kg dose of SCH 23390 markedly enhanced naltrexone (0.1 and 10.0 mg/kg)-induced hypodipsia, whilst the drug alone significantly decreased water intake at doses of 0.01 to 3.0 mg/kg, accompanied by marked motor dysfunction. Sulpiride (20.0 and 40.0 mg/kg) did not markedly affect water intake and naltrexone-induced hypodipsia. Consistent with previous results, apomorphine (0.3 mg/kg) alone was without marked effects, while it produced a marked potentiation of naltrexone (1.0 and 10.0 mg/kg)-induced hypodipsia. SCH 23390 (0.003 mg/kg) and sulpiride (40.0 mg/kg) completely antagonized the enhancing effects of apomorphine on naltrexone-induced hypodipsia. Similar effects were also seen in the latency to begin drinking. In contrast to the effects on naltrexone-induced hypodipsia, it appears that both dopamine D-1 and D-2 receptors play a key role in the effects of apomorphine on naltrexone-induced hypodipsia in the rat.