Abstract
A water extract of human placental membranes inhibited DNA synthesis and cell division in fibroblasts, lymphocytes, and epidermis. The effect occurred rapidly and was abolished by heating at 60°C. Gel filtration studies indicated the inhibitor had a molecular weight of about 70,000. Storage in aqueous solutions and treatment with trypsin resulted in marked loss of activity. No significant inhibition of RNA or protein synthesis could be demonstrated. The inhibitor did not exhibit cytotoxicity as judged by cytologic criteria and uptake of trypan blue, but cell death did occur after prolonged exposure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
