Abstract
D-Ala 2-Met-Enkephalinamide (DALA), a synthetic analog of met-enkephaline resistant to enzymatic degradation, was injected intraventricularly to sexually experienced male rats paired with receptive females. A dose of DALA of 6 μg which did not influence spontaneous motor activity, completely suppressed the copulatory behavior of all animals tested. A dose of 3 μg significantly increase mounting and intromission latencies, but did not influence other measures of the copulatory behavior. The effect of DALA was prevented by naloxone (1 mg/Kg), a specific inhibitor of opioid receptors. The results suggest that enkephalins may play a role in the regulation of copulatory behavior.
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