Abstract
Abstract: It has been reported that high‐dose administration of intravenous immunoglobulin (IVIG) is useful for the inhibition of complement‐dependent immune cytolysis, which is the first event of xenogeneic hyperacute rejection. We have found that monomeric peptide residues 289–292 and 282–292 from the second constant domain of the γ‐chain of the human IgG, part of the Clq binding sites, was also effective in inhibition of pig RBC lysis by human serum, and IgM‐rich IVIG (Pentaglobulin) was more active than IVIG in this assay.
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