Abstract
The objective of this study was to determine if dietary selenium could inhibit the induction of pulmonary cell proliferation by cigarette smoke in mice. Female A/J mice were fed purified diets containing 0.15, 0.5, or 2.0 mg/kg selenium in the form of sodium selenite. After 3 weeks, mice in each diet group were divided into two subgroups; one used as control while the other was exposed to cigarette smoke for five consecutive days and euthanized 3 days later. During this time mice were administered bromodeoxyuridine (BrdU) in the drinking water. After euthanasia, the left lung lobe was processed for serial sectioning and cell proliferation analysis. Cigarette smoke increased cell proliferation in the terminal bronchioles and large airways, but not in alveoli. Selenium inhibited cell proliferation in the terminal bronchioles and large airways areas. Increasing the dietary selenium level led to the increased selenium levels in the blood and lung, and increased glutathione peroxidase activity in the serum. Cytochrome P‐450 1A1 protein levels in the lung were increased by cigarette smoke but were not affected by dietary selenium. It is concluded that dietary selenium inhibits pulmonary cell proliferation caused by cigarette smoke exposure and that this inhibition may be related to selenium levels in the lung. (Supported by NIH CA125788, the China Scholarship Council, and the Kentucky Agricultural Experiment Station)
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