Abstract
This review is concerned with the effects of picornavirus infection on the biosynthesis of macromolecules in animal cells. Soon after infection of animal cells with a member of the picornavirus group, there is an inhibition of cellular RNA and protein synthesis. Later in infection, the synthesis of cellular DNA is also decreased. During this time, viral constituents are synthesized and assembly of viral progeny occurs. Late in infection, there is an irreversible loss of the capacity of the cell to synthesize any macromolecules, host or viral, and finally, the cell dies.
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