Abstract
AbstractAcridone alkaloids of plants indigenous to the Orient were isolated and purified, and their chemical structures were determined. A total of 50 acridones and their synthetic derivatives were subjected to rapid screening for inhibition of macromolecular synthesis using radiolabeled precursors of DNA, RNA and protein. These compounds were then studied to examine cell growth inhibition of human promyelocytic leukemic cells (HL‐60). Cytotoxicity was studied using the trypan blue exclusion method. Of 50 compounds evaluated for cell growth inhibition, 12 compounds showed IC50<10 μM; 12 compounds, 10‐20 μM; 8 compounds, 20‐100 μM; and 18 compounds, >100 μM.
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