Abstract
The acute, anti‐inflammatory effect of bradykinin, ellagic acid, hista‐mine, padutin ®, serotonin, trasylol® and trypsin was tested against carrageenin‐induced rat paw oedema, and the in vivo effects of the same substances on parameters of the plasma kinin system was also examined. The substances were injected intraperitoneally and oedema was induced half an hour later. Groups of 5 test‐ and 5 control rats were used, and measurements of initial paw volumes and of volumes after 1, 2 and 3 hours were used for calculating the inhibition values. All the substances tested, except padutin, inhibited the development of oedema and except for padutin and trasylol, caused a fall in total kininogen. Apart from bradykinin and padutin, the substances also reduced the amount of pre‐kallikrein. The kininogen fractions activated by rat plasma kallikrein and by rat urine kallikrein were determined in order to calculate the 3 kininogen fractions S1I, s1II and S2 (Briseid et al. 1970a). All the substances tested caused a fall in the amount of S1II and only trypsin in the amount of S1I, while none of the substances altered the amount of S2. A significant correlation between the effects on factors involved in the plasma kinin system and the anti‐oedema effects provides evidence for the presence of a causal relationship.
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