Abstract
Dental caries are initiated by water-insoluble glucan (IG) synthesis by glucosyltransferase (GTase) from mutans streptococci. We looked for browned foods and beverages inhibiting GTase and found that dark beer inhibited IG synthesis by 50% at 30 μL/mL under the standard assay conditions. An active substance was purified by ethanol precipitation and by DEAE-Toyopearl, Sepharose 4B, and Sephadex G-200 column chromatography, being obtained as a water-soluble, brown, and acidic powder. It was found to have a high molecular weight (about 120,000) and was a polysaccharide derivative formed by the Maillard reaction and caramelization.
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