Abstract
Effects of cis-dichlorodiammineplatinum-(II) ( cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation to dose, while cell viability remained unchanged. The binding of the ligands to specific receptors was not affected by cis-DDP. The results suggested that cis-DDP inhibited cap formation by blocking membrane movement of the ligand-receptor complexes.
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