Abstract
Tamm-Horsfall glycoprotein (THP) is the most abundant protein in the urine of healthy individuals, but whether it actually inhibits or promotes calcium oxalate monohydrate (COM) crystallization processes (reviewed in 1) has been the subject of a great deal of controversy. At higher pH and lower ionic strength, THP primarily inhibits COM crystal aggregation2, 3, whereas at lower pH and higher ionic strength, THP molecules are more polymerized and act as weaker inhibitors of COM crystal aggregation4. Viscosity measurements and molecular weight determinations have provided evidence that severely recurrent calcium renal stone formers excrete THPs with an abnormally high tendency to polymerize and thus with reduced inhibitory properties 4.
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