Abstract
Abstract Injection of the eukaryotic RNA polymerase inhibitor α-amanitin 24 hr before blood feeding inhibited both dopa decarboxylase activity and yolk deposition in Aedes aegypti oocytes. The primary action of the toxin was to completely suppress the trypsin-like activity which is normally induced by the blood meal. It was concluded that the adverse effects of α-amanitin on ovarian development were indirect and resulted from the inability of the treated animals to hydrolyse blood proteins. Actinomycin D also inhibited proteolytic enzymatic activity when it is injected 30 min after the blood meal. We postulate that normal blood meal-mediated ovarian development in Aedes is regulated at an ecdysterone-independent transcriptional level as well as an ecdysterone-dependent post-transcriptional level.
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