Abstract

Background and Aim: Hepatocellular carcinoma (HCC) is a type of liver cancer that accounts for 80% of primary liver malignancies. According to the WHO, 905677 new cases are discovered each year, with an 803180 mortality rate in 2020. Despite the multiple therapeutic options available, HCC treatment remains challenging due to its multifaceted pathophysiology and complexity caused by molecular and immunological heterogeneity. Overexpression of Apoptosis Antagonizing Transcription Factor (AATF) has been associated with HCC pathogenesis.

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