Abstract
All- trans retinoic acid (ATRA) induces granulocytic maturation of WEHI-3B D + leukemia cells and LiCl enhances this maturation, while WEHI-3B D − cells are non-responsive to ATRA. Transfection of SCL, expressed in D − but absent in D + cells, into D + cells, caused resistance to ATRA, while transfection of GATA-1 into D + cells produced resistance to the combination of ATRA and LiCl. SCL expression in D + cells did not induce the expression of c-Kit, a putative target gene for SCL. LiCl, known to inhibit some kinases by displacing Mg 2+, did not affect tyrosine kinase activity of the cytoplasmic domain of c-Kit.
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