Abstract
This chapter demonstrates the inhibition of adrenocortical responses following sciatic nerve stimulation in rats with complete and partial hypothalamic deafferentation. The chapter indicates that the adrenocortical discharge following sciatic nerve stimulation is totally inhibited by complete hypothalamic deafferentation and that the afferent input is mediated by anterior neural pathways entering the hypothalamus. Partial hypothalamic deafferentation has demonstrated that the adrenocortical responses were inhibited following sciatic stimulation in rats with anterolateral and anterior cuts, however no such effects were obtained with posterior and posterolateral deafferentations. With the purpose of determining to what extent afferent somatosensory connections to the hypothalamus participate in the activation of adrenocortical responses following sciatic nerve stimulation, the effects of this stimulus applied through chronically implanted electrodes were studied on plasma corticosterone levels in pentobarbital anesthetized intact animals and in rats with hypothalamic islands. In the same preparation anoxia, immobilization and ether-stress produced normal adrenocortical responses.
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