Abstract
SummaryThe stimulation of cyclic AMP synthesis in isolated rat adrenal cells prelabeled with 3H-adenine has been studied. Whereas adrenocorticotropin (ACTH) produces a very large increase in cyclic AMP levels, the 0-nitrophenyl sulfenyl derivative (NPS-ACTH) causes only a small increase in cyclic AMP formation. NPS-ACTH also inhibits the ACTH induced cyclic AMP synthesis effectively.
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