Abstract
Some antiallergic agents having protective action agaist anaphylaxis were found to inhibit NAD+-linked 15-hydroxyprostaglandin dehydrogenase partially purified from guinea pig lung. The concentrations required to inhibit the enzyme by 50% were 3.0 μM for baicalein, 9.8 μM for xanoxic acid and 350μM for disodium cromoglycate. The inhibitory effects of these compounds on 15-hydroxyprostaglandin dehydrogenase were greater than on cAMP phosphodiesterase activity in the same tissue. Inhibitory effects of flavonoids other than baicalein were also investigated.
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