Abstract
Thiocetamide and one of its metabolites, thioacetamide- S-oxide, were shown to inhibit δ-aminolevulinic acid (ALA) synthetase when administered in vivo to adult male mice. Thioacetamide and thioacetamide- S-oxide also inhibited the 3,5-dicarboethoxy-1,4-dihydrocollidine (DDC)-mediated induction of ALA synthetase when given either 1hr prior to or 3 hr after the administration of DDC. The results of these studies also indicate that thioacetamide- S-oxide is generally a more potent inhibitor of ALA synthetase than thioacetamide.
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