Abstract
Suspensions of separated canine renal tubules were used to study the effect of diatrizoate on the tubular cell uptake of para-aminohippurate (PAH) in vitro. Tubules incubated in a solution containing a modified Ringer-Krebs-bicarbonate solution (Ringer), diatrizoate and PAH consistently had a lower PAH uptake than tubules incubated in Ringer-PAH (control solution). Small differences in osmolality between the diatrizoate and control solutions were not primarily responsible for the impairment of PAH uptake. The results suggest: (1) Diatrizoate interferes with tubular cell PAH transport in vitro. (2) Diatrizoate does not cause a generalized deleterious effect on cell metabolism as judged by measurements of intracellular sodium and potassium concentration. (3) Competitive inhibition is not a likely mechanism for the diatrizoate inhibition of PAH uptake since prolonging the incubation of tubules in the diatrizoate medium resulted in an improvement in PAH uptake.
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