Inhibition in proper Ser and in PLCγ2 synthesis are the main for causing Osteoarthritis, diabetes and C-lymphocytic leukemia diseases

Abstract

Purpose of study: Understanding that the inhibition or mutation in S6K and in hydroponic acids ( Ser, Tyr, Pro... ), in BTK and in PLCγ1 will lead to inhibition in PLCγ2 and in Thromboxane-A 2 then will be the main reasons for chronic lymphocytic leukemia “CLL” disease, where proper S6K /BTK and PLCγ2 are main regulations for thromboxane-A synthesis and necessary for B-cells maturations and T-cells modulations. Also, it’s important to Understand main factors that cause and link the Osteoarthritis “OA” with diabetes which are the deficiency in Ser (hydrophobic) amino acids and the mutated S6K productions lead to deficiency or inhibition in Ser phosphorylation signaling which normally is the basis of Ser/Thr phosphorylation signalling which necessarily for Akt, for S6K1 synthesis and necessary for RORs and IFNs synthesis, and also necessary for proper PLCγ2 productions , where S6K is the main regulator for ATPase, for ribosomes, for OPA1 repair, and for proper PLCγ2 synthesis , that I have to note that the percentage of the shortages ratio of amino acids or in the increasing in positive linkages are the main ratio that can define the degree and type of specific disease which can differ from other diseases or can linked with the same Syndromes of other diseases. That also the shortage ratio between the beta Cytokines producions and the ratio of sudden high inflammations productions “and the type of its inflammatory molecules” have to be calculated and considered related to the patients ages (whether child, youth or old ages) and the duration of the chronic disease disease, that some can be confused to differentiate between auto-immune disease and regular disease problems diagnosis. That, There was a case of a child with 9-year-old who had a suspicion of loose of bone maturation and growth and has a sudden infection in the right lung and a lack of breathing with pain. It was found that there was a pulmonary abscesses in right lung and there was a development with the appearance of an air bag or “inflammatory fluid bag” surrounding respiratory cells in right side. The occurrence of sudden inflammations molecules and their growth was rapid enough faster than IFNs productions and faster than PLCγ2 productions due to to the age of the child, “Note some her regular treating doctors diagnosed her medical conditions as a type Autoimmune disease and she has weakened immunity due to sudden fast infection related to her young age”. Highlights: _increasing in PLCγ1 with Deficiency in Ser , deficiency in proper S6K, and decreasing in synthase activity with inhibition in PLCγ2 will reflect decreasing in anti-inflammatory processes, reflect Osteoarthritis and diabetes syndromes, and also inhibition in PLCγ2 will inhibit TXA2 synthesis and can be the main reason for CLL diseases. _proper healthy PLCγ2 are so necessary for increasing re-medulate immune efficiencies, and for re-modulate IgM and IgD antigen and T-cells functions , and also proper healthy PLCγ2 productions (which depend on PLCγ1 and BTK Biosynthesis) are so imp for recover osteoporosis and both Osteoarthritis and diabetes. _inhibition in PLCγ2 Bio-Synthesis can reflect decreasing or inhibition in Thromboxane-A 1 percentages and can lead to CLL diseases, Where, CLL characterized by inhibition in BTK which regulate PLCγ2 synthesis, inhibition in main antigen synthesis, and then inhibition in the proper normal Thromboxane-A synthesis (which regulated mainly by PLCγ1 and by BTK and then linked to IFNs productions and regulated by PLCγ2 proper producions). _Chronic lymphocytic leukemia (CLL) observed during treatment with B-cell receptor inhibitors pathway including inhibitor of Bruton’s tyrosine kinase-PLCγ2, where, CLL can be strongly linked to Osteoporosis “OA” and Linked to both Osteoarthritis and diabetes too.