Abstract
Interleukin-1β(IL-1β) is an important porinflammatory cytokine that exert wide biological functions in the central nervous system (CNS). Voltage-gated Ca<sup>2+</sup> channels in plasma membrane are essential components of Ca<sup>2+</sup> signal whose change on pathological conditions is closely related to processes of diseases. Although both IL-1βand Ca<sup>2+</sup> channels have key roles in injury and disease of the brain, so far their relations have been reported in few studies. The effects of IL-1βon Ca<sup>2+</sup> channels in cultured cortical neurons of rats were investigated using patch-clamp recording in present research. Our results showed that both 10 and 50 ng/mL of IL-1βtreatment inhibit the Ca<sup>2+</sup> currents in time and dose dependent manner, without the change of activation properties of voltage-gated Ca<sup>2+</sup> channels (VGCC)s.
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