Abstract
Oral administration of Picrorrhiza kurroa extract was found to reduce the hepatotoxicity and fibrosis induced by chronic administration of carbon tetrachloride and thioacetamide in rats significantly. This was evident from the decreased values of serum and liver lipid peroxides, alkaline phosphatase, and glutamate pyruvate transaminase. Moreover, elevated liver collagen hydroxyproline, which is a marker of fibrosis, was found to be decreased significantly by the oral administration of the P. kurroa extract. P. kurroa was found to be a potent inhibitor of lipid peroxide formation and to scavenge hydroxyl and superoxide radicals in vitro, and this free radical scavenging activity was implicated in the action of the extract. The results are indicative of the usefulness of the P. kurroa extract in conditions of liver fibrosis produced by various xenobiotic agents.
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