Abstract
A comparison has been made of the abilities of several neurotoxic and nontoxic phospholipases A2 from snake venoms to inhibit the intake of gamma-aminobutyric acid into synaptosomes from rat cerebral cortex. The neurotoxic phospholipase A2 inhibited GABA uptake more than the nontoxic enzymes did. However, there was a poor correlation between the measured specific enzyme activity of a phospholipase A2 and its ability to inhibit the uptake of GABA.
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