Abstract
Summary The mechanism of action of kasugamycin, an aminoglycosidic antibiotic, has been comparatively studied with those of other aminoglycosides. The initiation complex formation on 30S ribosomes is inhibited by kasugamycin but not by streptomycin, kanamycin or gentamicin, although the binding of fMet-tRNA to 70S ribosomes is inhibited both by kasugamycin and by streptomycin. The 70S complex formation is inhibited by kasugamycin but not by streptomycin when GTP is replaced by GMPPCP. The results indicate that the 30S initiation complex formation is a primary site of kasugamycin action but the other aminoglycosides interfere with a certain process after forming the complex.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
