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Abstract
Slices of rabbit caudate nucleus were preincubated with [ 3H]dopamine then superfused and stimulated electrically. Baclofen, GABA and gabapentin 10 −4 and 10 −3 mol/l reduced the stimulation-evoked overflow of tritium in a similar manner. The effects of the substances were reinvestigated while one of them was present in a high concentration throughout the superfusion. These interaction experiments showed that baclofen and GABA have a common presynaptic site of action which is different from that of gabapentin.
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