Abstract
The secretion of melanin-dispersing substance from the adenohypophyses of frogs, Rana pipiens Schreber, as determined by bioassay with frog skin, was inhibited by saline extracts of frog and rat cerebrum and hypothalamus, particularly by the latter. Isolated pars intermedia was similarly inhibited. However, rat pituitaries under similar conditions were neither inhibited nor stimulated by such extracts. The inhibitor of secretion in the frog appears to be something other than the usually considered neurohumors.
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