Inhibition by endotoxin of the mitration of peritoneal exudate cells from endotoxin sensitive mice.

Abstract

SummaryThe influence of various bacterial endotoxins on the migration of mouse peritoneal exudate cells has been examined. Pretreatment of cell donors with S. abortus-equi or E. coli endotoxins rendered cells, harvested 10 days later, more susceptible to inhibition by the respective endotoxins. This increased reactivity was not in evidence for cells harvested 5 or 20 days after treatment. Cells from S. marcescens endotoxin treated animals did not exhibit a change in their susceptibility to that endotoxin during the 20-day test period. These findings are entirely consistent with previous in vivo studies supporting the hypothesis that host reactivity to endotoxins has an origin in an acquired hypersensitivity of the delayed type.