Abstract
Chlorophyllin (CHL), a water soluble derivative of the green pigment chlorophyll, was evaluated for its antimutagenic activity towards benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). CHL suppressed dose-dependently the formation of 8-azaguanine-resistant mutant colonies in Salmonella typhimurium TM677 treated with BPDE. Under the same experimental conditions, the cytotoxicity of this direct-acting mutagen was concomitantly blunted by CHL. The protective effect of CHL against BPDE mutagenicity was confirmed in the Salmonella histidine+ reversion assay CHL also reduced the in vitro covalent binding of BPDE to DNA. Copyright © 1998 John Wiley & Sons, Ltd.
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