Abstract
The effect of castration on aflatoxin-induced hepatoma in CCl 4-treated CFN rats was investigated. After 40 days of recovery, rats castrated soon after weaning were given a total of 2.15 mg of aflatoxin B 1-equivalents in 10 doses during a 166-day treatment period. All rats were given 0.1 ml CCl 4 mixed with 0.1 ml of liquid paraffin at the same time treated animals were given aflatoxin. CCl 4 was given to potentiate the effect of aflatoxin. Deaths (20–80%) occurred in all groups before the experiment was terminated on day 396. The highest incidence of deaths (80%) occurred in intact rats of both sexes treated with aflatoxin, and hepatomas were found in all 4 survivors among these animals. No hepatomas were found in any of the 16 aflatoxin-treated surviving castrated rats (39% deaths), in 15 surviving intact control rats (35% deaths), and in 15 surviving castrated control rats (38% deaths).
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