Inhibiting of TACC3 Promotes Cell Proliferation, Cell Invasion and the EMT Pathway in Breast Cancer.

Qin Huo,Juan Wang,Ni Xie,Zhenwei Li,Siqi Chen,Jiaying Li

doi:10.3389/fgene.2021.640078

Abstract

Accumulating evidences indicate that transforming acidic coiled-coil 3 (TACC3) is a tumor-related gene, was highly expressed in a variety of human cancers, which is involved in cancer development. However, the potential role of TACC3 in breast cancer remains largely unknown. In the present study, we found that TACC3 was highly-expressed in breast cancer tissues, and its level was positively correlated with the clinical features of breast cancer patients. Specifically, TACC3 expression was significantly associated with the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) status, nodal status, the scarff-bloom-richardson (SBR) grade, nottingham prognostic index (NPI), age, subtypes, and triple-negative and basal-like status, suggesting that TACC3 may be a potential diagnostic indicator of breast cancer. Furthermore, functional studies have shown that inhibition of TACC3 can significantly promote the cell proliferation and viability of breast cancer cells. Moreover, TACC3 knockdown suppressed the expression of E-cadherin, but increased the expression of N-cadherin, Snail, ZEB1, and TWIST, which indicate that TACC3 may impact the migration of breast cancer cells in vitro. Taken together, these findings indicate that TACC3 may serve as a prognostic and therapeutic indicator of breast cancer.

Highlights

Breast cancer is the most common type of cancer in women around the world, and it is one of the cancers with the highest mortality rates among women in the world (Bray et al, 2018)
We examined the expression of transforming acidic coiled-coil 3 (TACC3) between breast tumors and adjacent normal tissues using the DriverDBv3 database
We found that TACC3 was strongly expressed in breast cancer patient tissues (Figure 2C), but negative in adjacent tissues

Summary

Introduction

Breast cancer is the most common type of cancer in women around the world, and it is one of the cancers with the highest mortality rates among women in the world (Bray et al, 2018). Metastasis is the primary cause of death in breast cancer patients (Huo et al, 2020). The current treatments have improved the survival rate and quality of life, the prognosis for patients with advanced cancer is still poor. It is important to study the potential mechanism of cancer occurrence and development (Zeng et al, 2018). TACC3 is a tumor-related gene related to cancer development (Song et al, 2016). This gene product can regulate the formation of microtubules throughout the cell cycle (Kinoshita et al, 2005; Lioutas and Vernos, 2013). Studies have shown that TACC3 is highly expressed in lung cancer

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Conclusion